Muhamad Fitri, Othman and Norasikin, Jamburi and Nornizar, Anuar and Syarifah, Abd Rahim and Nurul Hazwani, Rohalim (2016) Ibuprofen-Amino Acids Co-Crystal Screening Via Co-Grinding Methods. In: MATEC Web of Conferences: 5th International Conference on Chemical and Process Engineering (ICCPE 2016) , 23-25 May 2016 , Jeju Island, South Korea. pp. 1-6., 69 (03002). ISSN 2261-236X
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Abstract
The importance of pharmaceutical co-crystals now has been recognized in order to improve the research and development in pharmaceutical industries. Low solubility of active pharmaceutical ingredient (API) has led to the growth of new pharmaceutical co-crystals formation as it enhances the physicochemical properties of the API. In this works, preparation of new co-crystal formation between ibuprofen (IBP) with selected amino acid compounds were performed by using dry grinding and liquid assisted grinding (LAG) techniques. Ibuprofen (IBP) was selected as the API meanwhile glycine (GLY), L-alanine (ALA) and L-proline (PRO) were selected as co-crystal former (CCF) agents. The products of IBP-co-former from grinding experiments for the formation of co-crystals were characterized and verified using X-Ray Powder Diffraction (XRPD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infra-Red Spectroscopy (FTIR). The finding reveals that the IBP-PRO co-crystals have successfully formed. For IBP-PRO system, new crystalline peaks from XRPD were recorded at 2θ values of 4.374°, 5.436° and 10.944° from dry grinding technique and 4.41°, 5.436° and 10.962° for liquid assisted grinding (LAG) technique. A new melting point of 257.49 °C was discovered for IBP-ALA indicates the possibility of co-crystals formation. On the other hand, the analysis for IBP-GLY shows that no co-crystals formed in the system.
| Item Type: | Conference or Workshop Item (Speech) |
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| Uncontrolled Keywords: | co-crystals; Ibuprofen; grinding; Amino acids |
| Subjects: | T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Chemical & Natural Resources Engineering |
| Depositing User: | Mrs. Neng Sury Sulaiman |
| Date Deposited: | 05 Apr 2017 07:20 |
| Last Modified: | 05 Apr 2017 07:20 |
| URI: | http://umpir.ump.edu.my/id/eprint/14619 |
| Download Statistic: | View Download Statistics |
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