Nursyamirah, Abd Razak and Akhtar, Muhammad Nadeem and Nadiah, Abu and Wan, Yong Ho and Sheau, Wei Tan and Seema, Zareen and Saiful Nizam, Tajuddin and Kamariah, Long and Noorjahan Banu, Alitheen and Swee, Keong Yeap (2017) The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells. RSC Advances, 7 (57). pp. 36185-36192. ISSN 2046-2069. (Published)
|
PDF
The In Vivo Anti-Tumor Effect of Curcumin Derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene) Cyclohexanone (BHMC) on 4T1 Breast Cancer Cells.pdf Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
Curcumin is one of the promising natural products extracted from the rhizomes of curcuma longa and has been extensively investigated by researchers to explore its potential as a chemopreventive and therapeutic agent against several chronic diseases. To further enhance the cytotoxic potential of curcumin, its derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) has been synthesized and investigated, and its antitumor effect on tested on 4T1 challenged mice. BHMC was recorded with in vitro cytotoxicity on murine 4T1 breast cancer cells with IC50 value 13.66 mM, which was 2 times lower than curcumin after 72 hours of treatment. An in vivo study indicated that BHMC possessed antitumor effect on the 4T1 cells of the challenged mice by induction of apoptosis, antiproliferation, antiinflammation and antimetastasis. This effect is better compared to curcumin treatment at the same evaluated concentration. Thus, BHMC is a potential antitumor agent against breast cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | breast cancer cells; Curcumin; anti-tumor |
| Subjects: | Q Science > Q Science (General) |
| Faculty/Division: | Faculty of Industrial Sciences And Technology |
| Depositing User: | Mrs. Neng Sury Sulaiman |
| Date Deposited: | 31 Oct 2017 03:01 |
| Last Modified: | 07 Mar 2018 00:10 |
| URI: | http://umpir.ump.edu.my/id/eprint/18564 |
| Download Statistic: | View Download Statistics |
Actions (login required)
 |
View Item |