Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives

Hegde, Gurumurthy and Boodappa, Chandrakantha and Isloor, Arun M. and Shetty, Prakash and Sook, Fun Pang (2014) Synthesis and Biological Evaluation of Novel Substituted 1,3,4-thiadiazole and 2,6-di aryl substituted imidazo [2,1- b] [1,3,4]thiadiazole Derivatives. European Journal of Medicinal Chemistry, 71. pp. 316-323. ISSN 0223-5234 (prin); 1768-3254 (online). (Published)

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Synthesis and Biological Evaluation of Novel Substituted 1,3,4-Thiadiazole and 2,6-Di Aryl Substituted Imidazo [2,1-B] [1,3,4] Thiadiazole Derivatives.pdf
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Synthesis and Biological Evaluation of Novel Substituted 1,3,4-Thiadiazole and 2,6-Di Aryl Substituted Imidazo [2,1-B] [1,3,4] Thiadiazole Derivatives.pdf
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DOI/Official URL: http://dx.doi.org/10.1016/j.ejmech.2013.10.056

Abstract

A new series of N-[5-(4-(alkyl/aryl)-3-nitro-phenyl)-[1,3,4-thiadiazol-2-yl]-2,2-dimethyl-propionamide 4(ael) and 6-(4-Methoxy-phenyl)-2-(4-alkyl/aryl)-3-nitro-phenyl)-Imidazo [2,1-b] [1,3,4] thiadiazole 6(ael) were synthesized starting from 5-(4-Fluoro-3-nitro-phenyl)-[1,3,4] thiadiazole-2-ylamine. The synthesized compounds were characterized by IR, NMR, mass spectral and elemental analysis. All the compounds were tested for antibacterial and antifungal activities. The antimicrobial activities of the compounds were assessed by well plate method (zone of inhibition). Compounds 4a,4c and 6e,6g displayed appreciable activity at the concentration 0.5 - 1.0 mg/mL.

Item Type:	Article
Uncontrolled Keywords:	1,3,4-Thiadiazole; 2,6-Diaryl imidazo [2,1-b] [1,3,4] thiadiazole; Antibacterial; Antifungal activity
Subjects:	Q Science > QD Chemistry Q Science > QC Physics
Faculty/Division:	Faculty of Industrial Sciences And Technology
Depositing User:	Dr. Gurumurthy Hegde
Date Deposited:	08 Jan 2015 07:53
Last Modified:	17 May 2018 06:30
URI:	http://umpir.ump.edu.my/id/eprint/8073
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