Carbamazepine-Fumaric Acid Co-Crystal Screening Using Solution Based Method

Syarifah, Abd Rahim and Chou, C. Tan and Noor Ashila, Ramle (2016) Carbamazepine-Fumaric Acid Co-Crystal Screening Using Solution Based Method. MATEC Web of Conferences, 69. pp. 1-5. ISSN 2261-236X. (Published)

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Abstract

Co-crystals is a multi-component system which connected by non-covalent interactions, present physically as a solid form under ambient conditions. Nowadays, co-crystal has becoming as an alternative approach to improve the bioavailability of poor water soluble drugs especially for a weakly ionisable groups or neutral compounds. In this study the co-crystal screening was carried out for carbamazepine (CBZ) and fumaric acid (FUM) co-crystal former (CCF) using non-stoichiometric method (addition of CBZ to CCF saturated solution) and stoichiometric method (evaporation of 1:1 molar ratio of CBZ to CCF) in acetonitrile, ethyl acetate, propanol, ethanol and formic acid solvent systems. The crystals produced from the screening were characterized using Powder X-ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared (FT-IR). The PXRD analysis had confirmed that the co-crystal was successfully formed in both methods for all of the solvent system studied with an exception to formic acid in the stoichiometric method where no crystal was found precipitate. The findings from this study revealed that Form A and Form B of CBZ-FUM co-crystal had been successfully formed from different solvent systems.

Item Type: Article
Uncontrolled Keywords: carbamazepine, co-crystal, non-stoichiometry, non-stoichiometry.
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Chemical & Natural Resources Engineering
Depositing User: Mrs. Neng Sury Sulaiman
Date Deposited: 27 Dec 2016 02:56
Last Modified: 28 Dec 2016 07:29
URI: http://umpir.ump.edu.my/id/eprint/14072
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