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Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin Against Human Breast Cancer MCF-7 Cells in Vitro

Muhammad Yusran, Abdul Aziz and Nadiah, Abu and Yeap, Swee Keong and Ho, Wan Yong and Abdul Rahman, Omar and Nor Hadiani, Ismail and Syahida, Ahmad and Pirozyan, Mehdi R. and Akhtar, Muhammad Nadeem and Noorjahan Banu, Alitheen (2016) Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin Against Human Breast Cancer MCF-7 Cells in Vitro. Molecules, 21 (9). pp. 1-15. ISSN 1420-3049 (print); 1420-3049 (online)

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Abstract

Despite progressive research being done on drug therapy to treat breast cancer, the number of patients succumbing to the disease is still a major issue. Combinatorial treatment using different drugs and herbs to treat cancer patients is of major interest in scientists nowadays. Doxorubicin is one of the most used drugs to treat breast cancer patients. The combination of doxorubicin to other drugs such as tamoxifen has been reported. Nevertheless, the combination of doxorubicin with a natural product-derived agent has not been studied yet. Morinda citrifolia has always been sought out for its remarkable remedies. Damnacanthal, an anthraquinone that can be extracted from the roots of Morinda citrifolia is a promising compound that possesses a variety of biological properties. This study aimed to study the therapeutic effects of damnacanthal in combination with doxorubicin in breast cancer cells. Collectively, the combination of both these molecules enhanced the efficacy of induced cell death in MCF-7 as evidenced by the MTT assay, cell cycle, annexin V and expression of apoptosis-related genes and proteins. The effectiveness of doxorubicin as an anti-cancer drug was increased upon addition of damnacanthal. These results could provide a promising approach to treat breast cancer patients.

Item Type: Article
Uncontrolled Keywords: damnacanthal, doxorubicin, MCF-7, combination
Subjects: Q Science > Q Science (General)
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Mrs. Neng Sury Sulaiman
Date Deposited: 11 Jan 2017 06:42
Last Modified: 19 Apr 2018 01:06
URI: http://umpir.ump.edu.my/id/eprint/14412
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