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Bioassay-guided Isolation and Antioxidant Activity of Sulfur-containing Compounds from Clinacanthus nutans

Hazrulrizawati, Hamid and Izzah Hayati, Yahaya and M. M., Yusoff and Seema, Zareen (2016) Bioassay-guided Isolation and Antioxidant Activity of Sulfur-containing Compounds from Clinacanthus nutans. Journal of the Chinese Chemical Society, 63 (12). pp. 1033-1037. ISSN 2192-6549

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Abstract

Clinacanthus nutans has been used in traditional herbal medicine for cancer prevention, but the specific bioactive compounds responsible for the observed activities have not been explored. Different polar solvents such as methanol, chloroform, ethyl acetate, and hexane were used for the extraction. The extracts, fractions, and isolated compounds were subjected to DPPH and ferric reducing antioxidant potential (FRAP) assays. Methanol extracts show significant free-radical scavenging activity of 69.09% in DPPH and 56.49% FRAP. Purification of MeOH extracts afforded the fraction FB28 and two new sulfur-containing compounds, named clinamide D and E (1, 2). Compound (1) proved to be more active with an IC50 value for DPPH radical scavenging of 118.27 ± 0.01 µg/mL and reduction of Fe3+–TPTZ complex of 386.24 ± 0.02, higher than that of the standard ascorbic acid. Sulfur-containing compounds isolated from C. nutans is a potential natural antioxidant.

Item Type: Article
Uncontrolled Keywords: Clinacanthus nutans; Sulfur-c ontaining compounds; Antioxidant ; Belalai gajah
Subjects: Q Science > QD Chemistry
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Prof. Dr. Mashitah Mohd Yusoff
Date Deposited: 03 Feb 2017 03:08
Last Modified: 26 Jul 2018 07:50
URI: http://umpir.ump.edu.my/id/eprint/16242
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