Bromelain: from Production to Commercialisation

Aizi Nor Mazila, Ramli and Tuan Norsyalieza, Tuan Aznan and Rosli, Md. Illias (2016) Bromelain: from Production to Commercialisation. Journal of the Science of Food and Agriculture. pp. 1-10. (Published)

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Bromelain is a mixture of proteolytic enzymes found in pineapple (Ananas comosus) plants. It can be found in several parts of the pineapple plant, including the stem, fruit, leaves and peel. High demand for bromelain has resulted in gradual increases in bromelain production. These increases have led to the need for a bromelain production strategy that yields more purified bromelain at a lower cost and with fewer production steps. Previously, bromelain was purified by conventional centrifugation, ultrafiltration and lyophilisation. Recently, the development of more modern purification techniques such as gel filtration, ion exchange chromatography, affinity chromatography, aqueous two-phase extraction and reverse micelle chromatography has resulted in increased industrial bromelain production worldwide. In addition, recombinant DNA technology has emerged as an alternative strategy for producing large amounts of ultrapure bromelain. An up-to-date compilation of data regarding the commercialisation of bromelain in the clinical, pharmaceutical and industrial fields is provided in this review.

Item Type: Article
Uncontrolled Keywords: Pineapple; Bromelain; Production; Commercialisation
Subjects: S Agriculture > S Agriculture (General)
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Dr. Aizi Nor Mazila Ramli
Date Deposited: 24 Feb 2017 07:04
Last Modified: 26 Jul 2018 01:55
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