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Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro

Nadiah, Abu and Akhtar, Muhammad Nadeem and Swee, K. Yeap and Kian, Lam Lim and Wan, Yong Ho and Mohd Puad, Abdullah and Chai, Ling Ho and Abdul Rahman, Omar and Jamil, Ismail and Noorjahan Banu, Alitheen (2016) Flavokawain B Induced cytotoxicity in Two Breast Cancer Cell Lines, MCF-7 and MDA-MB231 and Inhibited the Metastatic Potential of MDA-MB231 via the Regulation of Several Tyrosine Kinases In vitro. BMC Complementary and Alternative Medicine, 16 (86). pp. 1-14. ISSN 1472-6882

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Abstract

Background The kava-kava plant (Piper methysticum) is traditionally consumed by the pacific islanders and has been linked to be involved in several biological activities. Flavokawain B is a unique chalcone, which can be found in the roots of the kava-kava plant. In this study, the operational mechanism of the anti-cancer activity of a synthetic Flavokawain B (FKB) on two breast cancer cell lines, MCF-7 and MDA-MB231 was investigated.

Item Type: Article
Uncontrolled Keywords: Breast cancer, Flavokawain, Proliferation, Metastasis, Tyrosine kinase
Subjects: Q Science > QR Microbiology
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Noorul Farina Arifin
Date Deposited: 23 Feb 2017 06:17
Last Modified: 17 Nov 2017 06:46
URI: http://umpir.ump.edu.my/id/eprint/16809
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