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Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs: A Mini Review

Hazrulrizawati, Hamid and Aizi Nor Mazila, Ramli and M. M., Yusoff (2017) Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs: A Mini Review. Frontiers in Pharmacology, 8 (96). pp. 1-7. ISSN 1663-9812

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Abstract

Depression is the most common illness observed in the elderly, adults, and children. Antidepressants prescribed are usually synthetic drugs and these can sometimes cause a wide range of unpleasant side effects. Current research is focussed on natural products from plants as they are a rich source of potent new drug leads. Besides Hypericum perforatum (St. John’s wort), the plants studied include Passiflora incarnata L. (passion flower), Mitragyna speciosa (kratom), Piper methysticum G. Forst (kava) and Valeriana officinalis L. Harman, harmol, harmine, harmalol and harmaline are indole alkaloids isolated from P. incarnata, while mitragynine is isolated from M. speciosa. The structure of isolated compounds from P. methysticum G. Forst and V. officinalis L. contains an indole moiety. The indole moiety is related to the neurotransmitter serotonin which is widely implicated for brain function and cognition as the endogenous receptor agonist. An imbalance in serotonin levels may influence mood in a way that leads to depression. The moiety is present in a number of antidepressants already on the market. Hence, the objective of this review is to discuss bioactive compounds containing the indole moiety from plants that can serve as potent antidepressants.

Item Type: Article
Uncontrolled Keywords: Indole alkaloids, antidepressant, Passiflora incarnata L, Mitragyna speciosa, Piper methysticum G. Forst, Valeriana officinalis L
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Dr. Hazrulrizawati Abd Hamid
Date Deposited: 15 Sep 2017 00:15
Last Modified: 26 Jul 2018 02:05
URI: http://umpir.ump.edu.my/id/eprint/17136
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