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Novel Compounds Targeting InhA for TB Therapy

Almatar, Manaf and Makky, Essam A. and Var, Isıl and Kayar, Begum and Koksal, Fatih (2018) Novel Compounds Targeting InhA for TB Therapy. Pharmacological Reports, 70 (2). pp. 217-226. ISSN 1734-1140

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Abstract

Tuberculosis (TB) is described as lethal disease in the world. Resistant to TB drugs is the main reason to have unfavourable outcomes in the treatment of TB. Therefore, new agents to replace existing drugs are urgently needed. Previous reports suggested that InhA inhibitors, an enoyl-ACP-reductase, might provide auspicious candidates which can be developed into novel antitubercular agents. In this review, we explain the role of InhA in the resistance of isoniazid. Furthermore, five classes of InhA inhibitors, which display novel binding modes and deliver evidence of their prosperous target engagement, have been debated.

Item Type: Article
Uncontrolled Keywords: Tuberculosis; Isoniazid resistance; Enoyl ACP reductase; InhA inhibitor; Novel drugs
Subjects: Q Science > Q Science (General)
Q Science > QR Microbiology
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Dr. Essam A. Makky
Date Deposited: 12 Jun 2018 02:13
Last Modified: 12 Jun 2018 02:13
URI: http://umpir.ump.edu.my/id/eprint/19673
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