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Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity

Taha, Muhammad and Sultan, Sadia and Mohamad, Azlan and Syed Adnan, Ali Shah and Jamil, Waqas and Swee, KeongYeap and Syahrul, Imran and Akhtar, Muhammad Nadeem and Seema, Zareen and Nor Hadiani, Ismail and Ali, Muhammad (2017) Synthesis of a Series of New 6-nitrobenzofuran-2-carbohydrazide Derivatives with Cytotoxic and Antioxidant Activity. New Horizons in Translational Medicine, 4 (1-4). pp. 23-30. ISSN 2307-5023

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Abstract

6-nitrobenzofuran-2-carbohydrazide Schiff base derivatives have been synthesized and their structure has been confirmed via H1NMR, Mass spectrometry and elemental (CHN/S) analysis. These synthesized analogs showed significant cytotoxic and antioxidant activity. Doxorubicin (IC50 = 0.94 ± 0.20 μM) and n-propyl gallate (IC50 = 30.30 ± 0.40 μM) were used as standard in cytotoxic and antioxidant activities, respectively. Compound 1 (IC50 = 3.30 ± 0.90 μM), 2 (IC50 = 2.70 ± 0.25 μM), 3 (IC50 = 2.70 ± 0.25 μM), 10 (IC50 = 2.70 ± 1.10 μM), 11 (IC50 = 1.00 ± 1.20 μM), and 17 (IC50 = 3.75 ± 0.90 μM) showed excellent while 21 (IC50 = 7.50 ± 0.60 μM) and 28 (IC50 = 7.50 ± 0.66 μM) showed moderate anti cancer activity. Furthermore, compound 10 (IC50 = 17.50 ± 0.85 μM), 11 (IC50 = 24.20 ± 0.55 μM), 12 (IC50 = 21.10 ± 1.58 μM), 13 (IC50 = 14.60 ± 0.32 μM), 14 (IC50 = 29.20 ± 0.75 μM) and 15 (IC50 = 9.26 ± 0.15 μM) showed better antioxidant activity than the standard n-propyl gallate. This study will be useful to develop potential lead molecules with cytotoxic and antioxidant potential.

Item Type: Article
Uncontrolled Keywords: 6-nitrobenzofuran-2-carbohydrazide; Cytotoxicity; Cytotoxic antioxidant
Subjects: Q Science > Q Science (General)
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Noorul Farina Arifin
Date Deposited: 29 Dec 2017 06:03
Last Modified: 05 Apr 2018 06:16
URI: http://umpir.ump.edu.my/id/eprint/19769
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