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Comparative structural analysis of fruit and stem bromelain from Ananas comosus

Aizi Nor Mazila, Ramli and Nor Hasmaliana, Abdul Manas and Azzmer Azzar, Abdul Hamid and Hazrulrizawati, Hamid and Rosli Md, Illias (2018) Comparative structural analysis of fruit and stem bromelain from Ananas comosus. Food Chemistry, 266. pp. 183-191. ISSN 0308-8146

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Abstract

Cysteine proteases in pineapple (Ananas comosus) plants are phytotherapeutical agents that demonstrate anti-edematous, anti-inflammatory, anti-thrombotic and fibrinolytic activities. Bromelain has been identified as an active component and as a major protease of A. comosus. Bromelain has gained wide acceptance and compliance as a phytotherapeutical drug. The proteolytic fraction of pineapple stem is termed stem bromelain, while the one presents in the fruit is known as fruit bromelain. The amino acid sequence and domain analysis of the fruit and stem bromelains demonstrated several differences and similarities of these cysteine protease family members. In addition, analysis of the modelled fruit (BAA21848) and stem (CAA08861) bromelains revealed the presence of unique properties of the predicted structures. Sequence analysis and structural prediction of stem and fruit bromelains of A. comosus along with the comparison of both structures provides a new insight on their distinct properties for industrial application.

Item Type: Article
Additional Information: Index by Scopus
Uncontrolled Keywords: Stem bromelain; Fruit bromelain; Amino acid analysis; 3D structure prediction
Subjects: Q Science > Q Science (General)
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Mrs. Neng Sury Sulaiman
Date Deposited: 11 Oct 2018 08:45
Last Modified: 11 Oct 2018 08:45
URI: http://umpir.ump.edu.my/id/eprint/22280
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