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Detection of virulence factors and β lactamase encoding genes among the clinical isolates of Pseudomonas aeruginosa

M. K. K., Fazlul and A., Najnin and Farzana, Yasmin and M. A., Rashid and S., Deepthi and C., Srikumar and Rashid, Shah Samiur and M. H. M., Nazmul (2018) Detection of virulence factors and β lactamase encoding genes among the clinical isolates of Pseudomonas aeruginosa. Journal of International Pharmaceutical Research, 45. pp. 190-202. ISSN 1674-0440

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Abstract

Background: Pseudomonas aeruginosa has emerged as a significant opportunistic bacterial pathogen that causes nosocomial infections in healthcare settings resulting in treatment failure throughout the world. This study was carried out to compare the relatedness between virulence characteristics and β-lactamase encoding genes producing Pseudomonas aeruginosa. Methods: A total of 120 P. aeruginosa isolates were obtained from both paediatric and adult patients of Selayang Hospital, Kuala Lumpur, Malaysia. Phenotypic methods were used to detect various virulence factors (Phospholipase, Hemolysin, Gelatinase, DNAse, and Biofilm). All the isolates were evaluated for production of extended spectrum beta-lactamase (ESBL) as well as metallo β-lactamase (MBL) by Double-disk synergy test (DDST) and E-test while AmpC β-lactamase production was detected by disk antagonism test.

Item Type: Article
Uncontrolled Keywords: Pseudomonas aeruginosa; ESBL; MBL; Virulence factors
Subjects: Q Science > Q Science (General)
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Noorul Farina Arifin
Date Deposited: 26 Nov 2018 05:05
Last Modified: 26 Nov 2018 08:31
URI: http://umpir.ump.edu.my/id/eprint/22918
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