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Microfluidic micro-well (size and shape) by numerical optimization for single cell applications: vertical trapping approach

James, Jasper A. and M., Sushmitha and R., Premkumar and Narayanamurthy, Vigneswaran and R., Kalpana (2017) Microfluidic micro-well (size and shape) by numerical optimization for single cell applications: vertical trapping approach. In: International Conference on Microelectronic Devices, Circuits and Systems (ICMDCS 2017), 10-12 August 2017 , Vellore, India. pp. 1-6.. ISBN 978-1-5386-1716-8

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Abstract

The paper focuses on the design of a biochip for Single Cell Analysis (SCA) using microfluidics. Several techniques have been developed for analysis of human cells. But most of these analyses are done on a group of cells assuming that all the cells within an isogenic cell population are homogenous. However, many evidences show that cellular heterogeneity occurs even within an isogenic cell population. Therefore, single cell analysis has been gaining a lot of importance in the recent past. The main objective is to design a micro-well with vertical trapping. The focus is on capturing a single cell by optimizing the shape and size of the micro-well and microchannel using hydrodynamics. The design simulation is done using COMSOL Multiphysics software. The paper provides a comparative analysis of various designs proposed, based on their performance and design parameters.

Item Type: Conference or Workshop Item (Speech)
Additional Information: Indexed by SCOPUS
Uncontrolled Keywords: Biochip; COMSOL Multiphysics; Micro-well; Microfluidics; Single Cell Analysis; Vertical trap
Subjects: T Technology > TK Electrical engineering. Electronics Nuclear engineering
Faculty/Division: Faculty of Electrical & Electronic Engineering
Depositing User: Mrs. Neng Sury Sulaiman
Date Deposited: 22 Apr 2019 02:08
Last Modified: 22 Apr 2019 02:08
URI: http://umpir.ump.edu.my/id/eprint/23060
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