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Ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts

Gnaneshwar, Puvala Vijayakumar and Sudakaran, Shruthi Vathaluru and Abisegapriyan, Sivasubramanian and Sherine, Jositta and Ramakrishna, Seeram and Mohd Fadzil, Abdul Rahim and M. M., Yusoff and Rajan, Jose and Venugopal, Jayarama Reddy (2019) Ramification of zinc oxide doped hydroxyapatite biocomposites for the mineralization of osteoblasts. Materials Science and Engineering: C, 96. pp. 337-346. ISSN 0928-4931

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Abstract

Far-flung evolution in tissue engineering enabled the development of bioactive and biodegradable materials to generate biocomposite nanofibrous scaffolds for bone repair and replacement therapies. Polymeric bioactive nanofibers are to biomimic the native extracellular matrix (ECM), delivering tremendous regenerative potentials for drug delivery and tissue engineering applications. It's been known from few decades that Zinc oxide (ZnO) nanoparticles are enhancing bone growth and providing proliferation of osteoblasts when incorporated with hydroxyapatite (HAp). We attempted to investigate the interaction between the human foetal osteoblasts (hFOB) with ZnO doped HAp incorporated biocomposite poly(L-lactic acid)-co-poly(ε-caprolactone) and silk fibroin (PLACL/SF) nanofibrous scaffolds for osteoblasts mineralization in bone tissue regeneration. The present study, we doped ZnO with HAp (ZnO(HAp) using the sol-gel ethanol condensation technique. The properties of PLACL/SF/ZnO(HAp) biocomposite nanofibrous scaffolds enhanced with doped and blended ZnO/HAp were characterized using Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), Contact angle and Tensile studies to determine the morphology, functionality, wettability and stability. The in vitro study results showed that the addition of ZnO and HAp enhances the secretion of bone mineral matrix (98%) with smaller fiber diameter (139.4 ± 27 nm) due to the presence of silk fibroin showing potential tensile properties (322.4%), and increased the proliferation of osteoblasts for bone tissue regeneration.

Item Type: Article
Additional Information: Indexed by SCOPUS
Uncontrolled Keywords: Bone tissue regeneration; Zinc oxide; Hydroxyapatite; Biocomposite; Osteoblasts; Mineralization
Subjects: Q Science > QD Chemistry
Q Science > QL Zoology
R Medicine > RZ Other systems of medicine
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Prof. Dr. Jose Rajan
Date Deposited: 07 Mar 2019 04:22
Last Modified: 19 Mar 2019 06:22
URI: http://umpir.ump.edu.my/id/eprint/24003
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