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Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering

Ezhilarasu, H. and Sadiq, A. and Ratheesh, G. and Sridhar, S. and Ramakrishna, Seeram and Mohd Hasbi, Ab. Rahim and M. M., Yusoff and Rajan, Jose and Venugopal, Jayarama Reddy (2019) Functionalized core/shell nanofibers for the differentiation of mesenchymal stem cells for vascular tissue engineering. Nanomedicine, 14 (2). pp. 201-214. ISSN 1743-5889

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Abstract

Aim: Atherosclerosis is a common cardiovascular disease causing medical problems globally leading to coronary artery bypass surgery. The present study is to fabricate core/shell nanofibers to encapsulate VEGF for the differentiation of mesenchymal stem cells (MSCs) into smooth muscle cells to develop vascular grafts. Materials & methods: The fabricated core/shell nanofibers contained polycaprolactone/gelatin as the shell, and silk fibroin/VEGF as the core materials. Results: The results observed that the core/shell nanofibers interact to differentiate MSCs into smooth muscle cells by the expression of vascular smooth muscle cell (VSMC) contractile proteins α-actinin, myosin and F-actin. Conclusion: The functionalized polycaprolactone/gelatin/silk fibroin/VEGF (250 ng) core/shell nanofibers were fabricated for the controlled release of VEGF in a persistent manner for the differentiation of MSCs into smooth muscle cells for vascular tissue engineering.

Item Type: Article
Additional Information: Hariharan Ezhilarasu, Asif Sadiq, Greeshma Ratheesh, Sreepathy Sridhar, Seeram Ramakrishna, Mohd Hasbi Ab. Rahim, Mashitah M. Yusoff, Rajan Jose & Venugopal Jayarama Reddy; Indexed by Scopus
Uncontrolled Keywords: α-actinin; core/shell nanofibers; gelatin; mesenchymal stem cells; myosin; polymers; silk fibroin; smooth muscle cells; vascular tissue engineering; VEGF
Subjects: Q Science > QD Chemistry
R Medicine > R Medicine (General)
R Medicine > RM Therapeutics. Pharmacology
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Mrs Norsaini Abdul Samat
Date Deposited: 14 Oct 2019 06:46
Last Modified: 14 Oct 2019 06:46
URI: http://umpir.ump.edu.my/id/eprint/24997
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