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Direct cell imprint lithography in superconductive carbon black polymer composites: Process optimization, characterization and in vitro toxicity analysis

Narayanamurthy, Vigneswaran and Fahmi, Samsuri and Firus Khan, Al'aina Yuhainis and Hairul Aini, Hamzah and Madia Baizura, Baharom and Kumary, T. V. and Anil Kumar, P. R. and Raj, Deepa K. (2019) Direct cell imprint lithography in superconductive carbon black polymer composites: Process optimization, characterization and in vitro toxicity analysis. Bioinspiration & Biomimetics, 15 (016002). pp. 1-19. ISSN 1748-3190

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Abstract

Cell imprint lithography (CIL) or cell replication plays a vital role in fields like biomimetic smart culture substrates, bone tissue engineering, cell guiding, cell adhesion, tissue engineering, cell microenvironments, tissue microenvironments, cell research, drug delivery, diagnostics, therapeutics and many other applications. Herein we report a new formulation of superconductive carbon black photopolymer composite and its characterization towards a CIL process technique. In this article, we demonstrated an approach of using a carbon nanoparticle-polymer composite (CPC) for patterning cells. It is observed that a 0.3 wt % load of carbon nanoparticles (CNPs) in a carbon polymer mixture (CPM) was optimal for cell-imprint replica fabrication. The electrical resistance of the 3-CPC (0.3 wt %) was reduced by 68% when compared to N-CPC (0 wt %). This method successfully replicated the single cell with sub-organelle scale. The shape of microvesicles, grooves, pores, blebs or microvilli on the cellular surface was patterned clearly. This technique delivers a free-standing cell feature substrate. In vitro evaluation of the polymer demonstrated it as an ideal candidate for biomimetic biomaterial applications. This approach also finds its application in study based on morphology, especially for drug delivery applications and for investigations based on molecular pathways.

Item Type: Article
Additional Information: Indexed by Scopus
Uncontrolled Keywords: Cell imprint lithography; Cell replication; Patterning cells; Molecular pathways
Subjects: T Technology > TK Electrical engineering. Electronics Nuclear engineering
Faculty/Division: Faculty of Electrical & Electronic Engineering
Institute of Postgraduate Studies
Depositing User: Mrs Norsaini Abdul Samat
Date Deposited: 12 Mar 2020 05:59
Last Modified: 12 Mar 2020 05:59
URI: http://umpir.ump.edu.my/id/eprint/26745
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