Tuning mechanical properties of seaweeds for hard capsules: A step forward for a sustainable drug delivery medium

Mohd Aiman, Hamdan and Khairatun Najwa, Mohd Amin and Rajan, Jose and Martin, Darren and Fatmawati, Adam (2021) Tuning mechanical properties of seaweeds for hard capsules: A step forward for a sustainable drug delivery medium. Food Hydrocolloids for Health, 1 (100023). pp. 1-10. ISSN 2667-0259. (Published)

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Abstract

At present, vegetarian hard capsules from hydroxypropyl methyl cellulose is highly attractive to consumer market. However, the production volume is still low due to expensive raw polymer materials. Most of the renewable polymers do not meet sufficient mechanical strength for developing hard capsules. This work demonstrates that the mechanical properties of carrageenan, a sea-based edible material known as seaweeds, could be enhanced by the addition of small amounts (<2 wt./v%) of cellulose nanocrystals (CNC) for developing hard capsules. The microstructure and mechanical properties of the cellulose toughened carrageenan films are systematically correlated to the rheology of the solution from which the films were prepared. Carrageenan films containing 1.6 wt./v% of CNC showed an optimum viscosity of 1.17 mPas with 58% higher tensile strength than films without CNC. The hard capsules thereby developed are stable to three types of antibiotics, which are amoxycillin 500 mg, ampicillin 500 mg, and doxycycline 100 mg. The carrageenan biocomposite hard capsule is suitable for human consumption based on the cytotoxicity test on human body. All the hard capsule samples showed excellent disintegration behavior in physiological conditions. These achievements pose promising directions for sustainable materials supply for pharmaceutical industries.

Item Type:	Article
Additional Information:	International Conference of Chemical Engineering and Industrial Biotechnology (ICCEIB 2020), Hotel Astana Kuala Lumpur, 9 - 11 Aug. 2020
Uncontrolled Keywords:	Renewable Biocomposite, Drug Delivery; Ultrasonication; Tensile Strength; Disintegration Test; Antibiotic Stability
Subjects:	T Technology > TP Chemical technology
Faculty/Division:	Institute of Postgraduate Studies Faculty of Chemical and Process Engineering Technology
Depositing User:	Pn. Hazlinda Abd Rahman
Date Deposited:	01 Sep 2021 01:38
Last Modified:	01 Sep 2021 01:38
URI:	http://umpir.ump.edu.my/id/eprint/28759
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