Nazikussabah, Zaharudin and Staerk, Dan and Dragsted, Lars Ove (2019) Inhibition of α-glucosidase activity by selected edible seaweeds and fucoxanthin. Food Chemistry, 270. pp. 481-486. ISSN 0308-8146. (Published)
|
Pdf
Inhibition of aglucosidase.pdf Download (128kB) | Preview |
Abstract
A 5 mg/mL solution of water, methanol and acetone extracts of seaweeds were used for α-glucosidase inhibition assay hyphenated with high performance liquid chromatography–mass spectrometry (HPLC–HRMS). The results showed acetone extracts of Undaria pinnatifida has the strongest inhibitory effect against α-glucosidase activity with IC50 0.08 ± 0.002 mg/mL. The active compound found in Undaria pinnatifida was identified as fucoxanthin. Analytical standard sample of fucoxanthin significantly inhibited α-glucosidase with IC50 value 0.047 ± 0.001 mg/mL. An inhibition kinetics study indicates that fucoxanthin is showing mixed-type inhibition. These results suggest that Undaria pinnatifida has a potential to inhibit α-glucosidase and may be used as a bioactive food ingredient for glycaemic control.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Seaweed, Glycaemic control, Hyperglycaemia, α-Glucosidase, Fucoxanthin |
| Subjects: | Q Science > QD Chemistry |
| Faculty/Division: | Faculty of Industrial Sciences And Technology |
| Depositing User: | Ms. Nazikussabah Zaharudin |
| Date Deposited: | 19 Nov 2020 01:46 |
| Last Modified: | 19 Nov 2020 01:46 |
| URI: | http://umpir.ump.edu.my/id/eprint/29668 |
| Download Statistic: | View Download Statistics |
Actions (login required)
 |
View Item |