Nuramira Fateha, Sukor and Rohayu, Jusoh and Nur Syahirah, Kamarudin (2022) Controlled release of niacinamide from fibrous silica nanocarrier in face serum formulation. In: The 6th National Conference for Postgraduate Research (NCON-PGR 2022) , 15 November 2022 , Virtual Conference, Universiti Malaysia Pahang, Malaysia. p. 74.. (In Press / Online First)
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Abstract
The current study offers a controlled release of niacinamide from fibrous silica (KCC-1) loaded in face serum formulation. Furthermore, three drug loading methods namely physical mixing, (Phy)/Nia-KCC-1, melting (Mel)/Nia-KCC-1 and solvent evaporation, (Sol)/Nia-KCC-1 were implemented and the percentage loading efficiency were compared. (Mel)/Nia-KCC-1 demonstrated highest percentage drug loading at 33%, followed by (Phy)/Nia-KCC-1 and (Sol)/Nia-KCC-1 at 25% and 17%, respectively. Likewise, the in vitro release study also revealed similar pattern with (Mel)/Nia-KCC-1 recorded highest percentage release at 29%, followed by (Phy)/Nia-KCC-1 and (Sol)/Nia-KCC-1 at 24% and 21%, respectively. As (Mel)/Nia-KCC-1 sample unveiled decent result in transporting the sample drug, the respective sample was then further loaded into the face serum formulation and the pH stability was observed for 7 days. The pH readings were at constant pH 4.3 throughout 7 days, in acceptance range according to the derma-cosmetic product that stated the effective pH is supposed to lies between pH 4 to pH 6. Therefore, it can be stated that the (Mel)/Nia-KCC-1 serum fulfilled the acceptance criteria of Ph requirement for the derma-cosmetics products.
| Item Type: | Conference or Workshop Item (Lecture) |
|---|---|
| Uncontrolled Keywords: | Controlled release; Niacinamide; Fibrous silica; Drug loading; Serum formulation. |
| Subjects: | Q Science > QD Chemistry T Technology > T Technology (General) T Technology > TA Engineering (General). Civil engineering (General) T Technology > TP Chemical technology |
| Faculty/Division: | Institute of Postgraduate Studies Faculty of Chemical and Process Engineering Technology |
| Depositing User: | Mr Muhamad Firdaus Janih@Jaini |
| Date Deposited: | 30 Jan 2023 08:25 |
| Last Modified: | 30 Jan 2023 08:25 |
| URI: | http://umpir.ump.edu.my/id/eprint/36797 |
| Download Statistic: | View Download Statistics |
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