Ultrasensitive aptasensor using electrospun MXene/polyvinylidene fluoride nanofiber composite for Ochratoxin A detection

Al Dhahebi, Adel Mohammed and Jose, Rajan and Mazli, Mustapha and Mohamed Shuaib, Mohamed Saheed (2022) Ultrasensitive aptasensor using electrospun MXene/polyvinylidene fluoride nanofiber composite for Ochratoxin A detection. Food Chemistry, 390 (133105). pp. 1-10. ISSN 03088146. (Published)

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Abstract

Ochratoxin A (OTA) has harmful effects to human and animal health; therefore, sensitive and selective detection of OTA is highly demanded. Herein, an ultrasensitive electrochemical aptasensor electrode comprising electrospun MXene/polyvinylidene fluoride (Ti3C2Tx/PVDF) nanofiber composite is presented. Addition of Ti3C2Tx up to 13% effectively increased the fiber diameter and lowered the β-phase of PVDF nanofibers, consequently lowering the charge transfer resistance. The nanofiber composite is then coated on the screen-printed carbon electrode to chemically functionalized with saline and aldehyde groups for efficient aptamer loading. The optimized aptasensor demonstrated sensitive detection of OTA over the dynamic concentration range from 1 fg mL−1 to 1 ng mL−1 with a limit of detection of 2.15 fg mL−1 and quantification limit of 6.52 fg mL−1, with high selectivity. The aptasensor could detect the OTA at femtogram per milliliter concentration in grape juice samples, demonstrating its enormous potential for OTA detection in food industry.

Item Type:	Article
Additional Information:	Indexed by Scopus
Uncontrolled Keywords:	Biosensor design; Electroactive materials; Food samples; Mycotoxin contamination; Piezoelectric sensor; Titanium carbide
Subjects:	Q Science > QD Chemistry
Faculty/Division:	Faculty of Industrial Sciences And Technology
Depositing User:	Prof. Dr. Jose Rajan
Date Deposited:	02 Aug 2023 02:54
Last Modified:	02 Aug 2023 02:54
URI:	http://umpir.ump.edu.my/id/eprint/38056
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