Tabynov, Kairat and Tailakova, Elmira and Rakhmatullayeva, Guliza and Bolatbekov, Turlan and Lim, Yeow Hong and Fomin, Gleb and Babayeva, Meruert and Valenta, Rudolf and Tabynov, Kaissar (2025) Comparison of rArt v 1-based sublingual and subcutaneous immunotherapy in a murine model of asthma. npj Vaccines, 10 (1). pp. 1-10. ISSN 2059-0105. (Published)
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Abstract
Mugwort-allergic patients frequently experience severe respiratory allergies due to sensitization to the major allergen Art v 1, with allergen-specific immunotherapy (ASIT) as the only causal treatment to halt disease progression. This study evaluated the effects of subcutaneous (SCIT) and sublingual (SLIT) ASIT with purified recombinant Art v 1 (rArt v 1) in a murine model of mugwort pollen of asthma. BALB/c mice were sensitized with Artemisia vulgaris pollen extract and treated with either rArt v 1-based SCIT adjuvanted with Montanide ISA-51, rArt v 1-based SLIT, an extract-based commercial SLIT vaccine, or PBS. Both rArt v 1-based SCIT and SLIT improved lung pathology and reduced airway reactivity following allergen challenge, with rArt v 1-based SCIT inducing Th1-polarized immune responses marked by increased IFN-γ production and rArt v 1-specific IgG1/IgG2a, while SLIT induced stronger mucosal IgA responses. These findings highlight the therapeutic potential of rArt v 1-based ASIT for mugwort allergy.
| Item Type: | Article |
|---|---|
| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Gamma interferon; Immunoglobulin E; Immunoglobulin G1; Immunoglobulin G2a; Montanide ISA 51 |
| Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine R Medicine > RM Therapeutics. Pharmacology |
| Faculty/Division: | Faculty of Industrial Sciences And Technology |
| Depositing User: | Mrs. Nurul Hamira Abd Razak |
| Date Deposited: | 18 Jul 2025 07:29 |
| Last Modified: | 18 Jul 2025 07:29 |
| URI: | http://umpir.ump.edu.my/id/eprint/45117 |
| Download Statistic: | View Download Statistics |
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