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Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release

Lokman, Faradianna E. and Harvest, F. Gu and Wan Nazaimoon, Wan Mohamud and M. M., Yusoff and Keh, Leong Chia and Claes-Göran, Östenson (2013) Antidiabetic Effect of Oral Borapetol B Compound, Isolated from the Plant Tinospora crispa, by Stimulating Insulin Release. Evidence-Based Complementary and Alternative Medicine , 2013.

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Abstract

To evaluate the antidiabetic properties of borapetol B known as compound 1 (C1) isolated from Tinospora crispa in normoglycemic control Wistar (W) and spontaneously type 2 diabetic Goto-Kakizaki (GK) rats. Methods. The effect of C1 on blood glucose and plasma insulin was assessed by an oral glucose tolerance test. The effect of C1 on insulin secretion was assessed by batch incubation and perifusion experiments using isolated pancreatic islets. Results. An acute oral administration of C1 improved blood glucose levels in treated versus placebo groups with areas under glucose curves 0–120 min being versus  mmol/L () and versus  mmol/L () in W and GK rats, respectively. Plasma insulin levels were increased by 2-fold in treated W and GK rats versus placebo group at 30 min (). C1 dose-dependently increased insulin secretion from W and GK isolated islets at 3.3 mM and 16.7 mM glucose. The perifusions of isolated islets indicated that C1 did not cause leakage of insulin by damaging islet beta cells (). Conclusion. This study provides evidence that borapetol B (C1) has antidiabetic properties mainly due to its stimulation of insulin release.

Item Type: Article
Uncontrolled Keywords: Antidiabetic Effect;Borapetol B Compound;Oral Glucose Tolerance Test;Plant Tinospora Crispa
Subjects: Q Science > QD Chemistry
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Prof. Dr. Mashitah Mohd Yusoff
Date Deposited: 31 Dec 2013 06:10
Last Modified: 27 Jul 2018 01:42
URI: http://umpir.ump.edu.my/id/eprint/4695
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