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The Flavokawains: Uprising Medicinal Chalcones

Akhtar, Muhammad Nadeem and Nadiah, Abu and Wan, Yong Ho and Swee, Keong Yeap and Mohd Puad, Abdullah and Abdul Rahman, Omar and Noorjahan Banu, Alitheen (2013) The Flavokawains: Uprising Medicinal Chalcones. Cancer Cell International, 13 (201). pp. 1-7. ISSN 1475-2867 (print); 1475-2867 (online)

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Abstract

lant-based compounds have been in the spotlight in search of new and promising drugs. Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and C. Flavokawain B also exerts antinociceptive effects as well as anti-inflammation properties. This mini-review attempts to discuss the biological properties of all the flavokawains that have been reported.

Item Type: Article
Additional Information: Indexed in Scopus, Google Scholar, ISI. IF: 2.093
Uncontrolled Keywords: Anti-cancer; Anti-inflammation; Apoptosis; Flavokawain; Kava-kava
Subjects: Q Science > QR Microbiology
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Noorul Farina Arifin
Date Deposited: 31 Mar 2014 07:25
Last Modified: 19 Apr 2018 00:58
URI: http://umpir.ump.edu.my/id/eprint/5209
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