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Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model

Akhtar, Muhammad Nadeem and Noor Azlina, Abu Bakar and Mohd Roslan, Sulaiman and Nordin, Lajis and Akira Omar, Farouk (2013) Participation of Large Ca2+ Activated Potassium Channel in Antinociceptive Activity of Chalcone Derivative (3-(2, 5-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one) DMPF-1 Action in Mice Model. In: 3rd International Conference on Medical, Biological and Pharmaceutical Sciences (ICMBPS'2013), 4-5 January 2013 , Bali, Indonesia. pp. 204-206..

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Abstract

The role of potassium channels in nociceptive activity was proposed in the past decade. Various type of potassium channel has been found to exert different action in propogation of action potential in nervous system. As DMPF-1, a chalcone derivative possesses antinociceptive properties. The mechanism of its action has been carried out to verify the pathway involved. The present study addressed the role of potassium channel in the contribution of the antinociceptive action of DMPF-1. The involvement of potassium channel was evaluated using acetic acid-induced abdominal writhing test.The animals were pretreated with charybdotoxin (large Ca2+ activated potassium channel blocker)(0.04mg/kg, i.p) or apamin (small Ca2+ activated potassium channel blocker)(0.02mg/kg, i.p.) 15 minutes before administration of DMPF-1. It was demonstrated that the challenge of DMPF-1 treated group with charybdotoxin has reversed the antinociceptive activity of this novel chalcone, which indicates the possible participation of large Ca2+ activated potassium channel in antinociceptive effect cause by DMPF-1 but not through small Ca2+ activated potassium channel.

Item Type: Conference or Workshop Item (Speech)
Uncontrolled Keywords: DMPF-1; Abdominal writhing test; Antinociceptive and Potassium channel
Subjects: Q Science > QR Microbiology
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Noorul Farina Arifin
Date Deposited: 31 Mar 2014 08:06
Last Modified: 19 Apr 2018 00:59
URI: http://umpir.ump.edu.my/id/eprint/5213
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