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Parameter Estimation Using Improved Differential Evolution And Bacterial Foraging Algorithms To Model Tyrosine Production In Mus Musculus(Mouse)

Jia, Xing Yeoh and Chuii, Khim Chong and Mohd Saberi, Mohamad and Yee, Wen Choon and Lian, En Chai and Safaai, Deris and Zuwairie, Ibrahim (2015) Parameter Estimation Using Improved Differential Evolution And Bacterial Foraging Algorithms To Model Tyrosine Production In Mus Musculus(Mouse). Jurnal Teknologi (Sciences and Engineering), 72 (1). pp. 49-56. ISSN 0127-9696 (print); 2180-3722 (online)

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Abstract

The hybrid of Differential Evolution algorithm with Kalman Filtering and Bacterial Foraging algorithm is a novel global optimisation method implemented to obtain the best kinetic parameter value. The proposed algorithm is then used to model tyrosine production in Musmusculus (mouse) by using a dataset, the JAK/STAT(Janus Kinase Signal Transducer and Activator of Transcription) signal transduction pathway. Global optimisation is a method to identify the optimal kinetic parameter in ordinary differential equation. From the ordinary parameter of biomathematical field, there are many unknown parameters, and commonly, the parameter is in nonlinear form. Global optimisation method includes differential evolution algorithm, which will be used in this research. Kalman Filter and Bacterial Foraging algorithm helps in handling noise data and convergences faster respectively in the conventional Differential Evolution. The results from this experiment show estimated optimal kinetic parameters values, shorter computation time, and better accuracy of simulated results compared with other estimation algorithms.

Item Type: Article
Uncontrolled Keywords: Parameter estimation, differential evolution algorithm, bacterial foraging algorithm, kalman filtering algorithm, modelling, metabolic engineering, bioinformatics, artificial intelligence
Subjects: T Technology > TK Electrical engineering. Electronics Nuclear engineering
Faculty/Division: Faculty of Electrical & Electronic Engineering
Depositing User: Mrs. Neng Sury Sulaiman
Date Deposited: 30 May 2016 03:32
Last Modified: 08 Feb 2018 01:25
URI: http://umpir.ump.edu.my/id/eprint/8356
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