Insulin Sensitivity as a Model-Based Marker for Sepsis Diagnosis

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Abstract

Sepsis is highly associated with microcirculatory dysfunction, which normally results in organ failure and increased risk of death. Importantly, early goal-directed therapy observed lower mortality rates in septic shock patients compared to those assigned to standard therapy. Currently, it is almost impossible to diagnose a patient at the onset of sepsis due to the lack of real-time metrics with high sensitivity and specificity. Patient condition is mostly determined by clinician experience and observation of patient reaction to treatment. In this study, a model-based insulin sensitivity profile is used to identify the relation between individual metabolic conditions to their sepsis status. The hour-to-hour variation of insulin sensitivity is highly independent of the treatment received by the patient and may represent a metabolic status for real-time diagnosis of sepsis. The hour-to-hour variation of insulin sensitivity profile is analyzed with sepsis score calculated according to the definition provided by ACCP/SCCM. P-values of various sepsis score group are computed using Mann-Whitney test. Cumulative distribution function of insulin sensitivity shows separation between different sepsis score and more distinguishable at a higher sepsis score compared to the lower sepsis score.

Item Type:	Article
Additional Information:	9th IFAC Symposium on Biological and Medical Systems BMS 2015 — Berlin, Germany, 31 August-2 September 2015
Uncontrolled Keywords:	Sepsis; Insulin Sensitivity
Subjects:	T Technology > TJ Mechanical engineering and machinery
Faculty/Division:	Faculty of Mechanical Engineering
Depositing User:	Mrs. Neng Sury Sulaiman
Date Deposited:	03 Dec 2015 01:45
Last Modified:	17 Jul 2019 02:52
URI:	http://umpir.ump.edu.my/id/eprint/11198
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