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A Newton Cooperative Genetic Algorithm Method for In Silico Optimization of Metabolic Pathway Production

Mohd Arfian, Ismail and Safaai, Deris and Mohd Saberi, Mohamad and Afnizanfaizal, Abdullah (2015) A Newton Cooperative Genetic Algorithm Method for In Silico Optimization of Metabolic Pathway Production. PLoS ONE, 10 (5). pp. 1-19. ISSN 1932-6203

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Abstract

This paper presents an in silico optimization method of metabolic pathway production. The metabolic pathway can be represented by a mathematical model known as the generalized mass action model, which leads to a complex nonlinear equations system. The optimization process becomes difficult when steady state and the constraints of the components in the metabolic pathway are involved. To deal with this situation, this paper presents an in silico optimization method, namely the Newton Cooperative Genetic Algorithm (NCGA). The NCGA used Newton method in dealing with the metabolic pathway, and then integrated genetic algorithm and cooperative co-evolutionary algorithm. The proposed method was experimentally applied on the benchmark metabolic pathways, and the results showed that the NCGA achieved better results compared to the existing methods.

Item Type: Article
Subjects: Q Science > QA Mathematics > QA75 Electronic computers. Computer science
Q Science > QD Chemistry
Faculty/Division: Faculty of Computer System And Software Engineering
Depositing User: Dr. Mohd Arfian Ismail
Date Deposited: 17 Mar 2016 07:48
Last Modified: 27 Mar 2018 03:45
URI: http://umpir.ump.edu.my/id/eprint/11777
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