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Synthesis and Cytotoxic Effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 Breast Cancer Cell Lines

Akhtar, Muhammad Nadeem and Ali Salim, Landa Zeenelabdin and Swee, Keong Yeap and Nadiah, Abu and Seema, Zareen and Kong, Mun Lo and Addila, Abu Bakar and Noorjahan Banu, Alitheen (2017) Synthesis and Cytotoxic Effects of (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in MDA-MB231 and MCF-7 Breast Cancer Cell Lines. Phytochemistry Letters, 19. pp. 145-150. ISSN 1874-3900

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Abstract

A chalcone derivative, (E)-3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)-prop-2-en-1-one (DMMF) was synthesized and evaluated against various cancerous cell lines including colon adenocarcinoma (HT-29), myloplasticleukemia (HL60), breast cancer (MCF-7 and MDA-MB231), normal hepatic cell (WRL-68) and normal breast cell (MCF-10A). The structure of DMMF was determined by EI-MS, 1H NMR and single X-ray crystallographic techniques. The DMMF possessed the highest cytotoxic effect against MCF-7 breast cancer cell (2.01 ± 1.53 μg/mL) and lowest against normal hepatic WRL-68 and breast cell lines after 24 h of treatment. Induction of apoptosis and regulation of cell cycle progression results indicates the significant increase in early apoptosis and G2/M arrest after 48 h of treatment in MCF-7 cells. Meanwhile, in MDA-MB231 cells, there was an increase in Sub G0/G1 cells population and early/late apoptotic cells upon treatment with DMMF. Additionally, DMMF effectively induced G2/M cell cycle arrest in MCF-7 cells and apoptosis in both MCF-7 and MDA-MB231 cells.

Item Type: Article
Uncontrolled Keywords: Synthesis of DMMF; Cytotoxicity; MCF-7; Apoptosis; Single x-ray crystallography
Subjects: Q Science > Q Science (General)
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Mrs. Neng Sury Sulaiman
Date Deposited: 16 Jun 2017 03:47
Last Modified: 18 Apr 2018 03:59
URI: http://umpir.ump.edu.my/id/eprint/16454
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