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Abstract
The present study describes several novel 2,5-biaryl-3-hexylthiophene derivatives (3a-i) synthesized via a Pd(0)-catalyzed Suzuki cross-coupling reaction in moderate to good yields. The novel compounds were also analyzed for their anti-thrombolytic, haemolytic, and biofilm inhibition activities. In addition, the anti-tumor activity was also evaluated in vitro for newly-synthesized compounds, where 3-hexyl-2,5-bis(4-(methylthio)phenyl)thiophene exhibited the best anti-tumor activity against 4T1 cells with IC50 value of 16 μM. Moreover, 2,5-bis(4-methylphenyl)-3-hexylthiophene showed the highest activity against MCF-7 cells with an IC50 value of 26.2 μM. On the other hand, the compound 2,5-bis(4-chloropheny)-3-hexylthiophene exhibited excellent biofilm inhibition activity. Furthermore, the compound 2,5-bis(3-chloro-4-fluorophenyl)-3-hexylthiophene also exhibited better anti-thrombolytic and hemolytic activity results as compared to the other newly-synthesized compounds.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Suzuki cross-coupling reaction; 2,5-biaryl-3-hexylthiophene derivatives; anti-tumor; biofilm inhibition; haemolysis; anti-thrombolytic |
| Subjects: | Q Science > QR Microbiology |
| Faculty/Division: | Faculty of Industrial Sciences And Technology |
| Depositing User: | Noorul Farina Arifin |
| Date Deposited: | 24 Feb 2017 02:49 |
| Last Modified: | 02 Nov 2017 07:21 |
| URI: | http://umpir.ump.edu.my/id/eprint/16833 |
| Download Statistic: | View Download Statistics |
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