Effect of Cooling Rates on Shape and Crystal Size Distributions of Mefenamic Acid Polymorph in Ethyl Acetate

Siti Kholijah, Abdul Mudalip and Fatmawati, Adam and Jamal, Parveen and Mohd Rushdi, Abu Bakar and Norliyana, Amran and Siti Zubaidah, Sulaiman and Rohaida, Che Man and Zatul Iffah, Mohd Arshad and Shalyda, Md Shaarani (2017) Effect of Cooling Rates on Shape and Crystal Size Distributions of Mefenamic Acid Polymorph in Ethyl Acetate. In: IOP Conference Series: Materials Science and Engineering, The 2nd International Conference on Materials Engineering and Nanotechnology, 12-14 May 2017 , Kuala Lumpur, Malaysia. pp. 1-5., 205 (012025). ISSN 1757-8981 (Print), 1757-899X (Online)

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This study investigate the effect of cooling rates on mefenamic acid crystallisation in ethyl acetate. The cooling rate was varied from 0.2 to 5 °C/min. The in-line conductivity system and turbidity system were employed to detect the onset of the crystallization process. The crystals produced were analysed using optical microscopy and Fourier transform infrared spectroscopy (FTIR). It was found that the crystals produced at different cooling rates were needle-like and exhibit polymorphic form type I. However, the aspect ratio and crystal size distributions were varied with the increased of cooling rate. A high crystals aspect ratio and narrower CSD (100−900 μm) was obtained at cooling rate of 0.5 °C/min. Thus, can be suggested as the most suitable cooling rate for crystallization of mefenamic acid in ethyl acetate.

Item Type: Conference or Workshop Item (Lecture)
Uncontrolled Keywords: Mefenamic Acid; cooling rates
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Chemical & Natural Resources Engineering
Depositing User: Dr. Siti Kholijah Abdul Mudolip
Date Deposited: 22 Jun 2017 08:04
Last Modified: 16 Aug 2017 03:01
URI: http://umpir.ump.edu.my/id/eprint/18006
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