Chahal, Sugandha and Jahir Hussain, Fathima Shahitha and M. M., Yusoff and Mohammad Syaiful Bahari, Abdull Rasad and Anuj, Kumar (2017) Nanohydroxyapatite-coated Hydroxyethyl Cellulose/poly (vinyl) Alcohol Electrospun Scaffolds and Their Cellular Response. International Journal of Polymeric Materials and Polymeric Biomaterials, 66 (3). pp. 115-122. ISSN 0091-4037(Print); 1563-535X(Online). (Published)
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Abstract
The present study focused on the preparation of nanohydroxyapatite (nHA)-coated hydroxyethyl cellulose/polyvinyl alcohol (HEC/PVA) nanofibrous scaffolds for bone tissue engineering application. The electrospun HEC/PVA scaffolds were mineralized via alternate soaking process. FESEM revealed that the nHA was formed uniformly over the nanofibers. The nHA mineralization enhanced the tensile strength and reduced the elongation at breakage of scaffolds. The wettability of the nanofibrous scaffolds was significantly improved. The in vitro biocompatibility of scaffolds was evaluated with human osteosarcoma cells. nHA-coated scaffolds had a favorable effect on the proliferation and differentiation of osteosarcoma cell and could be a potential candidate for bone regeneration.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Bone tissue engineering, electrospinning, hydroxyethyl cellulose, nanohydroxyapatite coatings |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Faculty/Division: | Faculty of Industrial Sciences And Technology |
| Depositing User: | Prof. Dr. Mashitah Mohd Yusoff |
| Date Deposited: | 04 Jan 2018 04:01 |
| Last Modified: | 24 Apr 2018 08:11 |
| URI: | http://umpir.ump.edu.my/id/eprint/19820 |
| Download Statistic: | View Download Statistics |
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