Ghawanmeh, Abdullah A. and K. F., Chong and Sarkar, Shaheen M. and Muntaz, Abu Bakar and Rizafizah, Othaman and Rozida, M. Khalid (2018) Colchicine Prodrugs and Codrugs: Chemistry and Bioactivities. European Journal of Medicinal Chemistry, 144. pp. 229-242. ISSN 0223-5234. (Published)
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Abstract
Antimitotic colchicine possesses low therapeutic index due to high toxicity effects in non-target cell. However, diverse colchicine analogs have been derivatized as intentions for toxicity reduction and structure-activity relationship (SAR) studying. Hybrid system of colchicine structure with nontoxic biofunctional compounds modified further affords a new entity in chemical structure with enhanced activity and selectivity. Moreover, nanocarrier formulation strategies have been used for colchicine delivery. This review paper focuses on colchicine nanoformulation, chemical synthesis of colchicine prodrugs and codrugs with different linkers, highlights linker chemical nature and biological activity of synthesized compounds. Additionally, classification of colchicine prodrugs based on type of conjugates is discussed, as biopolymers prodrugs,fluorescent prodrug, metal complexes prodrug, metal-labile prodrug and bioconjugate prodrug. Finally, we briefly summarized the biological importance of colchicine nanoformulation, colchicine prodrugs and codrugs. ©
| Item Type: | Article |
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| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Colchicine; Prodrugs; Codrugs; Biological activities |
| Subjects: | Q Science > QD Chemistry |
| Faculty/Division: | Faculty of Industrial Sciences And Technology |
| Depositing User: | Dr. Chong Kwok Feng |
| Date Deposited: | 18 Jan 2018 01:23 |
| Last Modified: | 25 Oct 2018 01:08 |
| URI: | http://umpir.ump.edu.my/id/eprint/19831 |
| Download Statistic: | View Download Statistics |
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