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Thermal Characteristic Evaluation of Different Ascorbic Acid Crystal Habits

Shajaratul Jahriah, Hassan and Fatmawati, Adam and M. R., Abu Bakar (2018) Thermal Characteristic Evaluation of Different Ascorbic Acid Crystal Habits. Journal of Chemical Engineering and Industrial Biotechnology (JCEIB), 3. pp. 50-59. ISSN 0126-8139

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Melting temperature (Tmelt) and enthalpy of fussion (ΔHf) are important parameters to determine the quality and the thermal stability of active pharmaceutical ingredient (API) crystals. In this study, different habit of ascorbic acid was prepared by using different polar solvents namely water, methanol, ethanol and 2-propanol. Ascorbic acid crystal was then been physically and thermally characterized by using microscopic analysis, thermo gravimetric analysis (TGA) and differential scanning calometry analysis (DSC). This provides an insight into the formation of crystal habit across four different polar protic solvents. The ascorbic acid is found to grow as a cubic or prism crystal when grown in water that provides high hydrogen bond between solvent and solute. As the polarity of the solvents decrease, the hydrogen bond weaken and the width of the crystal become narrower, forming almost a needle like crystal. The thermal stability of ascorbic acid crystal is found to be the most stable when ascorbic acid is crystallized from water (prism) and the weakest from 2-Propanol (needle) due to the molecule arrangement in crystal lattice in which resulted from decreasing intermolecular forces in the liquid phase.

Item Type: Article
Uncontrolled Keywords: ascorbic acid, crystal habit, thermal analysis, intermolecular forces
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Chemical & Natural Resources Engineering
Depositing User: Noorul Farina Arifin
Date Deposited: 27 Jun 2018 03:05
Last Modified: 02 May 2019 08:07
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