Effects of Solvents on Polymorphism and Shape of Mefenamic Acid Crystals

Siti Kholijah, Abdul Mudalip and Mohd Rushdi, Abu Bakar and Jamal, Parveen and Fatmawati, Adam and Rohaida, Che Man and Siti Zubaidah, Sulaiman and Zatul Iffah, Mohd Arshad and Shalyda, Md Shaarani (2018) Effects of Solvents on Polymorphism and Shape of Mefenamic Acid Crystals. In: MATEC Web of Conferences: Malaysia Technical Universities Conference on Engineering and Technology (MUCET 2017), 6-7 December 2017 , Penang, Malaysia. pp. 1-6., 150 (02004). ISSN 2261-236X

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Mefenamic acid [2-(2, 3-dimethylphenyl) amino benzoic acid] is an active pharmaceutical compound that exist in different polymorphic form and shape. In this work the effect of solvents on polymorphism and shape of mefenamic acid crystals were examined. The solvents used were ethanol, isopropanol, ethyl acetate, dimethyl acetamide, dimethyl formamide, and acetone. Natural cooling was employed during the crystallisation process. The crystals produced were dried and analysed using optical microscopy, differential scanning calorimetry, thermal gravimetric analysis, x-ray powder diffraction (XRPD) and fourier transform infrared spectroscopy (FTIR). The analysis confirmed that the crystals obtained using ethyl acetate, ethanol, isopropanol, and acetone are pure Form I with a needle-like flat shape. Meanwhile, the crystallisation using DMF produced polymorphic Form II in cubic shape.

Item Type: Conference or Workshop Item (Lecture)
Uncontrolled Keywords: Mefenamic acid; Polymorphism; crystallisation process;
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Chemical & Natural Resources Engineering
Depositing User: Dr. Siti Kholijah Abdul Mudolip
Date Deposited: 14 Aug 2018 08:23
Last Modified: 14 Aug 2018 08:23
URI: http://umpir.ump.edu.my/id/eprint/21943
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