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Solubility and thermodynamic function of carbamazepine-saccharin (CBZ-SAC) co-crystal in ethanolic solution

Fatinah, Ab Rahman and Engku Nadia, Engku Mat Nasir and Syarifah, Abd Rahim and Raihana Z., Edros and Nornizar, Anuar (2018) Solubility and thermodynamic function of carbamazepine-saccharin (CBZ-SAC) co-crystal in ethanolic solution. In: 13th International Workshop of The Crystal Growth of Organic Material, 27 - 30 Ogos 2018 , Korea University, Seoul, Korea. pp. 1-11.. (Unpublished)

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Abstract

The aim of study was to assess solubility and thermodynamic function of CBZ-SAC co-crystal in varying SAC concentrations in ethanolic solution at temperatures (25-50 oC). Experimental solubilities of CBZ-SAC co-crystal were determined by gravimetric and high performance liquid chromatography (HPLC) methods. Experimental solubilities of co-crystal in mole fraction from HPLC method were correlated well with Van’t Hoff model. The solubilities of co-crystal were obtained highest in CBZ : SAC with ratio of 1.00 : 1.00 and the co-crystal solubility is higher than the pure form of CBZ (Fig.1) [1]. Based on the apparent thermodynamic analysis parameter, it was indicated an “endothermic and entropy-driven dissolution” of CBZ-SAC co-crystal [2,3,4]. From these results, CBZ-SAC co-crystal has been considered freely soluble in ethanol solution with non-SAC excess.

Item Type: Conference or Workshop Item (Speech)
Uncontrolled Keywords: Hermodynamic; Ethanolic solution
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Chemical & Natural Resources Engineering
Faculty of Engineering Technology
Depositing User: Pn. Hazlinda Abd Rahman
Date Deposited: 06 Dec 2018 08:58
Last Modified: 06 Dec 2018 08:58
URI: http://umpir.ump.edu.my/id/eprint/22192
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