Fatinah, Ab Rahman and Engku Nadia, Engku Mat Nasir and Syarifah, Abd Rahim and Raihana Z., Edros and Nornizar, Anuar (2018) Solubility and thermodynamic function of carbamazepine-saccharin (CBZ-SAC) co-crystal in ethanolic solution. In: 13th International Workshop of The Crystal Growth of Organic Material , 27 - 30 Ogos 2018 , Korea University, Seoul, Korea. pp. 1-11.. (Unpublished)
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Abstract
The aim of study was to assess solubility and thermodynamic function of CBZ-SAC co-crystal in varying SAC concentrations in ethanolic solution at temperatures (25-50 oC). Experimental solubilities of CBZ-SAC co-crystal were determined by gravimetric and high performance liquid chromatography (HPLC) methods. Experimental solubilities of co-crystal in mole fraction from HPLC method were correlated well with Van’t Hoff model. The solubilities of co-crystal were obtained highest in CBZ : SAC with ratio of 1.00 : 1.00 and the co-crystal solubility is higher than the pure form of CBZ (Fig.1) [1]. Based on the apparent thermodynamic analysis parameter, it was indicated an “endothermic and entropy-driven dissolution” of CBZ-SAC co-crystal [2,3,4]. From these results, CBZ-SAC co-crystal has been considered freely soluble in ethanol solution with non-SAC excess.
| Item Type: | Conference or Workshop Item (Speech) |
|---|---|
| Uncontrolled Keywords: | Hermodynamic; Ethanolic solution |
| Subjects: | T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Chemical & Natural Resources Engineering Faculty of Engineering Technology Institute of Postgraduate Studies |
| Depositing User: | Pn. Hazlinda Abd Rahman |
| Date Deposited: | 06 Dec 2018 08:58 |
| Last Modified: | 30 Oct 2019 07:39 |
| URI: | http://umpir.ump.edu.my/id/eprint/22192 |
| Download Statistic: | View Download Statistics |
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