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In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities

Azad, A. K. and Laboni, Farhina Rahman and Rashid, Harun and Ferdous, Sahena and Rashid, Shah Samiur and Nurkhalida, Kamal and Labu, Zubair Khalid and Islam, M. S. and Sarker, Zaidul Islam (2018) In vitro evaluation of Cuscuta reflexa Roxb. forthrombolytic, antioxidant, membrane stabilizingand antimicrobial activities. Natural Product Research: Formerly Natural Product Letters. pp. 1-4. ISSN 1478-6419 (print); 1478-6427 (online) (In Press)

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Abstract

The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83 μg/mL while the standard ascorbic acid was 2.48 µg/mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p > 0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50 mg of GAE/g).

Item Type: Article
Uncontrolled Keywords: Cuscutareflexa; hrombolytic; antioxidant; membrane stabilizing; anti-microbial activity
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Dr. Shah Samiur Rashid
Date Deposited: 11 Feb 2019 02:35
Last Modified: 11 Feb 2019 02:35
URI: http://umpir.ump.edu.my/id/eprint/24086
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