AL-japairai, Khater Ahmed Saeed and Chatterjee, Bappaditya and Mahmood, Syed and Almurisi, Samah Hamed (2021) A bioanalytical method for quantification of telmisartan in rat plasma; development, validation and application to pharmacokinetic study. Research J. Pharm. and Tech, 14 (4). pp. 2139-2144. ISSN 0974-360X. (Published)
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Abstract
The telmisartan was determined in a rat plasma using developed and validated a reversed-phase high performance liquid chromatographic (HPLC). The pre-treatment of the plasma sample involving liquid-liquid extraction using ethanol as the extracting solvent. The HPLC method validation has been shown a linear calibration curve over a plasma concentrations range of 0.7 to 10µg/mL with a correlation coefficient of 0.9979, the limit of detection and the limit of quantification were determined to be 0.025µg/ml and 0.07µg/ml, respectively. The precision and accuracy were in an acceptable limit. The pharmacokinetic parameters of telmisartan were adequately evaluated following a single oral dose (4mg/kg) in Sprague-Dawley rats. The results observed conclude that the developed bioanalytical HPLC method is appropriate and applicable as an analytical tool in the pharmacokinetic study of telmisartan.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Telmisartan, HPLC, Validation, Bioanalytical method, Rat plasma |
| Subjects: | Q Science > Q Science (General) |
| Faculty/Division: | Faculty of Chemical and Process Engineering Technology |
| Depositing User: | Mr. Mohd Ariffin Abdul Aziz |
| Date Deposited: | 15 Jul 2021 09:15 |
| Last Modified: | 15 Jul 2021 09:15 |
| URI: | http://umpir.ump.edu.my/id/eprint/25861 |
| Download Statistic: | View Download Statistics |
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