UMP Institutional Repository

Insights on the synthesis of asymmetric curcumin derivatives and their biological activities

Poh, Yen Khor and Mohd F. F., Mohd Aluwi and Kamal, Rullah and Kok, Wai Lam (2019) Insights on the synthesis of asymmetric curcumin derivatives and their biological activities. European Journal of Medicinal Chemistry, 183. ISSN 0223-5234

[img]
Preview
Pdf
Insights on the synthesis of asymmetric curcumin derivatives .pdf

Download (267kB) | Preview

Abstract

Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine.

Item Type: Article
Additional Information: Indexed by Scopus
Uncontrolled Keywords: Asymmetric curcumin; Monoketone; Diketone; Synthesis; Bioactivity
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
T Technology > TP Chemical technology
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Mrs Norsaini Abdul Samat
Date Deposited: 27 Nov 2019 02:32
Last Modified: 27 Nov 2019 02:32
URI: http://umpir.ump.edu.my/id/eprint/26063
Download Statistic: View Download Statistics

Actions (login required)

View Item View Item