Poh, Yen Khor and Mohd F. F., Mohd Aluwi and Kamal, Rullah and Kok, Wai Lam (2019) Insights on the synthesis of asymmetric curcumin derivatives and their biological activities. European Journal of Medicinal Chemistry, 183. ISSN 0223-5234. (Published)
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Abstract
Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine.
| Item Type: | Article |
|---|---|
| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Asymmetric curcumin; Monoketone; Diketone; Synthesis; Bioactivity |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology R Medicine > RS Pharmacy and materia medica T Technology > TP Chemical technology |
| Faculty/Division: | Faculty of Industrial Sciences And Technology |
| Depositing User: | Mrs Norsaini Abdul Samat |
| Date Deposited: | 27 Nov 2019 02:32 |
| Last Modified: | 27 Nov 2019 02:32 |
| URI: | http://umpir.ump.edu.my/id/eprint/26063 |
| Download Statistic: | View Download Statistics |
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