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Selective oxidation of glycerol to mesoxalic acid by laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system : effect of process conditions and the kinetic modeling

Hong, Chi Shein and Chin, S. Y. and Cheng, C. K. and Chua, Gek Kee (2019) Selective oxidation of glycerol to mesoxalic acid by laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system : effect of process conditions and the kinetic modeling. Chemical Engineering Communications, 206 (12). pp. 1645-1660. ISSN 0098-6445 (print); 1563-5201 (online)

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Abstract

A pharmaceutical importance compound, mesoxalic acid, can be produced through selective oxidation of glycerol using laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system. Since mesoxalic acid is the fourth product in the serial oxidation, identification of the reaction conditions and its’ kinetic to maximize the production is essential. Hence, the objective of this study is to examine the effects of process conditions on the distribution of the products and the kinetic. Mesoxalic acid attained was 0.0712 M (>200% of control) at 19 °C, pH 5.5, 1:3 of glycerol/TEMPO ratio and TEMPO/laccase ratio of 9:3. To conclude, a moderate temperature that preserves the activity of laccase would favor the formation of mesoxalic acid. The serial chemical reactions could be expressed by a power law rate obtained via MATLAB through fitting of the experimental kinetic data. Oxidising from tartronic acid to mesoxalic acid was found to require higher activation energy (25.06 kJ/mol) as compared to other steps.

Item Type: Article
Additional Information: Indexed by Scopus
Uncontrolled Keywords: Glycerol; Laccase; TEMPO; Kinetic model; Mesoxalic acid; Selective oxidation
Subjects: Q Science > QD Chemistry
T Technology > TP Chemical technology
Faculty/Division: Centre of Excellence: Centre of Excellence for Advanced Research in Fluid Flow
Faculty of Chemical & Natural Resources Engineering
Institute of Postgraduate Studies
Depositing User: Mrs Norsaini Abdul Samat
Date Deposited: 06 Dec 2019 09:01
Last Modified: 06 Dec 2019 09:01
URI: http://umpir.ump.edu.my/id/eprint/26220
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