Effects of stent design on LDL accumulation at the carotid artery bifurcation

Nasrul Hadi, Johari and Menichini, Claudia and Hamady, Mohamad and Xu, Xiao Y. (2019) Effects of stent design on LDL accumulation at the carotid artery bifurcation. In: 6th International Conference on Computational and Mathematical Biomedical Engineering (CMBE 2019) , 10-12 June 2019 , Japan. pp. 1-4.. (Unpublished)

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Abstract

Restenosis typically occurs in regions of low and oscillating wall shear stress which also favours the accumulation of atherogenic macromolecules such as low-density lipoprotein (LDL). This study aims to determine how stent strut design may affect in-stent restenosis at the carotid artery bifurcation following carotid artery stenting (CAS) by means of computational simulation. LDL concentrations were compared for post-stent carotid and the contralateral models reconstructed from patient-specific images. Our results show that closed-cell stent designs are more likely to create atheroprone and procoagulant flow conditions than open-cell designs due to larger area exposed to high LDL concentration.

Item Type: Conference or Workshop Item (Lecture)
Uncontrolled Keywords: Stent Design; Carotid Artery Stenting; Low-Density Lipoprotein
Subjects: T Technology > TJ Mechanical engineering and machinery
Faculty/Division: Faculty of Mechanical Engineering
Depositing User: Pn. Hazlinda Abd Rahman
Date Deposited: 23 Dec 2019 07:19
Last Modified: 23 Dec 2019 07:19
URI: http://umpir.ump.edu.my/id/eprint/26483
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