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Effect of Humidity on Formation of Electrospun Polycaprolactone Nanofiber Embedded with Curcumin using Needdleless Electrospinning

Ramakrishnan, Ramprasath and Ramakrishnan, Praveena and Ranganathan, Balu and Tan, Cowen and Sridhar, T. M. and Jolius, Gimbun (2019) Effect of Humidity on Formation of Electrospun Polycaprolactone Nanofiber Embedded with Curcumin using Needdleless Electrospinning. Materials Today: Proceedings, 19. 1241 - 1246. ISSN 2214-7853

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Abstract

This paper presents the effect of humidity on electrospun polycaprolactone (PCL) nanofiber formation using needleless electrospinning for drug delivery application. The nanofiber was made using a NS Lab needleless electrospinning working at the applied voltage of 45 kV. Polycaprolactone in dichloromethane was the polymer used with curcumin as the embedding model drug. Morphology of the fiber was analyzed using scanning electron microscopy and the fiber size distribution was studied using Fiber Metric image analysis tool. An increase in fiber diameter from 100 nm to 145 nm was observed when the humidity factor was raised from 40 RH to 60 RH. The fibers produced are also much more uniform at 60 humidity. The model drug, curcumin was loaded into a PCL nanofiber with entrapment efficiency up to 93. The controlled release of curcumin from the scaffold under physiological simulated conditions shows a significant release of curcumin within 48 hours of test. This work may serve as a useful guide to obtain a high-quality nanofiber from needleless electrospinning process for drug delivery application.

Item Type: Article
Additional Information: International Conference on Chemical Sciences and Engineering: Advance and New Materials, ICCSE 2018, 7-8 November 2018, Ramada Plaza Hotel Melaka Malaysia
Uncontrolled Keywords: Nanofiber, humidity, PCL-DCM, fiber size distribution, surface morphology, controlled release, curcumin
Subjects: T Technology > TP Chemical technology
Faculty/Division: Centre of Excellence: Centre of Excellence for Advanced Research in Fluid Flow
Faculty of Chemical & Natural Resources Engineering
Institute of Postgraduate Studies
Depositing User: P. M. Dr. Jolius Gimbun
Date Deposited: 27 Mar 2020 08:59
Last Modified: 27 Mar 2020 09:07
URI: http://umpir.ump.edu.my/id/eprint/27510
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