Karim Khan, Md Fazlul and Kabir, M. Nomani and Rashid, Shah Samiur and Tayan, Omar and Mohammad Nazmul Hasan, Maziz (2020) Computational investigation on protein sequence of non-O157 VTEC for potentiality of vaccine production. In: IEEE International Conference on Automatic Control and Intelligent Systems (I2CACIS 2020) , 20-20 June 2020 , Shah Alam, Selangor, Malaysia. pp. 57-61.. ISBN 978-1-7281-6133-4
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Abstract
Computational method can be used for investigation of the protein sequences for developing a vaccine against infections. In this present study, a protein derived from non-O157 Verotoxin-producing E. coli (VTEC) was identified as a potential vaccine candidate that can be used to evaluate their immunogenicity and protective capability against VTEC infections. Identification of potential B-cell epitopes for promising vaccine was carried out by evaluating the protein derived from non-O157 VTEC with the methods of beta turns, hydropathicity, surface accessibility and antigenicity. The methods were implemented in MATLAB. Our test results demonstrated that the VTEC-derived protein has plausible characteristics which provide significant insights for further investigations and will assist in finding potential drug targets/vaccine candidates.
| Item Type: | Conference or Workshop Item (Lecture) |
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| Uncontrolled Keywords: | Modeling; Protein sequencing, Verotoxinproducing E-coli; B-cell epitopes. |
| Subjects: | Q Science > QA Mathematics > QA75 Electronic computers. Computer science |
| Faculty/Division: | Faculty of Computing |
| Depositing User: | Dr. Muhammad Nomani Kabir |
| Date Deposited: | 24 Sep 2020 08:24 |
| Last Modified: | 13 Dec 2022 07:49 |
| URI: | http://umpir.ump.edu.my/id/eprint/29304 |
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