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Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children

Roslund, Marja I. and Puhakka, Riikka and Grönroos, Mira and Nurminen, Noora and Oikarinen, Sami and Ahmad Mahfuz, Gazali and Cinek, Ondřej and Kramná, Lenka and Siter, Nathan and Vari, Heli K. and Soininen, Laura and Parajuli, Anirudra and Rajaniemi, Juho and Kinnunen, Tuure and Laitinen, Olli H. and Hyöty, Heikki and Sinkkonen, Aki (2020) Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children. Sciences Advances, 6 (42). pp. 1-10. ISSN 2375-2548

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Abstract

As the incidence of immune-mediated diseases has increased rapidly in developed societies, there is an unmet need for novel prophylactic practices to fight against these maladies. This study is the first human intervention trial in which urban environmental biodiversity was manipulated to examine its effects on the commensal microbiome and immunoregulation in children. We analyzed changes in the skin and gut microbiota and blood immune markers of children during a 28-day biodiversity intervention. Children in standard urban and nature-oriented daycare centers were analyzed for comparison. The intervention diversified both the environmental and skin Gammaproteobacterial communities, which, in turn, were associated with increases in plasma TGF-1 levels and the proportion of regulatory T cells. The plasma IL-10:IL-17A ratio increased among intervention children during the trial. Our findings suggest that biodiversity intervention enhances immunoregulatory pathways and provide an incentive for future prophylactic approaches to reduce the risk of immune-mediated diseases in urban societies.

Item Type: Article
Uncontrolled Keywords: Immune regulation; commensal microbiota; immunoregulation; gammaproteobacterial
Subjects: R Medicine > RA Public aspects of medicine
R Medicine > RB Pathology
R Medicine > RJ Pediatrics
T Technology > TP Chemical technology
Faculty/Division: Faculty of Industrial Sciences And Technology
Depositing User: Ms. Ratna Wilis Haryati Mustapa
Date Deposited: 20 Oct 2020 03:28
Last Modified: 20 Oct 2020 03:28
URI: http://umpir.ump.edu.my/id/eprint/29638
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