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Optimization of lovastatin in solid-state fermentation using oil palm frond

Nur Fathin Shamirah, Daud and Farhan, Mohd Said and J. M., Ho (2020) Optimization of lovastatin in solid-state fermentation using oil palm frond. In: IOP Conference Series: Materials Science and Engineering, Energy Security and Chemical Engineering Congress, 17-19 July 2019 , Kuala Lumpur, Malaysia. pp. 1-11., 736 (022056). ISSN 1757-899X

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Abstract

Lovastatin plays a role in lowering the cholesterol level in the human blood, especially the bad cholesterol or low density lipoproteins (LDL). Concurrently, lovastatin increase the good cholesterol or high density lipoproteins (HDL), to prevent the formation of plaque inside the blood vessels. The objective of this research was to experimentally optimize the lovastatin compound produced by Monascus purpureus FTC5357 under solid state fermentation (SSF) using oil palm frond (OPF). In order to identify the optimal condition to produce lovastatin, four parameters which were pH, initial moisture content, peptone and potassium, were optimized using Box–Behnken design. Based on the ANOVA analysis performed, initial moisture content, potassium and peptone contributed significantly to the lovastatin production. Meanwhile, pH had the least impact to the lovastatin production.. Peptone pronounced to be the most contributed factor, as the lovastatin production increased with the increasing of peptone in the substrate. Under optimized condition (pH 5.50, moisture content at 60%, 3.40 g of potassium, and 3.30 g of peptone) maximum lovastatin yield was 45.84 µg/g. The lovastatin produced through SSF using OPF as a substrate by Monascus purpureus FTC 5357 has a great potential to be utilized as a source of lovastatin in future.

Item Type: Conference or Workshop Item (Lecture)
Additional Information: Indexed by Scopus
Uncontrolled Keywords: Low Density Lipoproteins (LDL); High Density Lipoproteins (HDL); Solid State Fermentation (SSF)
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Chemical & Natural Resources Engineering
Institute of Postgraduate Studies
Depositing User: Pn. Hazlinda Abd Rahman
Date Deposited: 16 Feb 2021 07:51
Last Modified: 16 Feb 2021 07:51
URI: http://umpir.ump.edu.my/id/eprint/29912
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