Ahmad, Hajar Fauzan Bin (2019) The Gut Microbiome of Older Danish Adults – with Particular Focus on the Gut Mycobiome --- [Thesisi]. PhD thesis, University of Copenhagen, Denmark (Contributors, UNSPECIFIED: UNSPECIFIED).
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Abstract
The human gut is home for plethora of microbes including prokaryotic and eukaryotic organisms across all domains of the tree of life. This complex community is known as the gut microbiome (GM). Nowadays, the advances in high-throughput sequencing technology allow for studies not limited to bacteria, but also fungi, archaea, viruses and parasites in various settings across age groups, life-styles, diets, and geographical regions have been studied. Gut microbial dysbiosis have been linked to frailty in elderly, but their possible association with host health is little understood. During the course of life, imbalances in the GM is associated with significant phenotypic effects for the host such as development of metabolic disorders like obesity, elevated blood pressure, changes in serum lipids and sugar metabolism, infections, overall losses of muscle mass and functional and general physiological decline. Understanding how these disorders have been orchestrated by the interplay between prokaryotic and eukaryotic communities is of great interest with the aim of elucidating mechanistic approaches to prevent frailty and improve quality of life through healthy ageing. Generally, our work involves high throughput sequencing and conventional microbiology-based approaches for GM characterization, with special focus on prokaryote and eukaryote communities in association with dietary, metabolome, life-styles and clinical characteristics at baseline and during a 1-year intervention study investigating the effect of whey supplementation and physical training activity.
| Item Type: | Thesis (PhD) |
|---|---|
| Subjects: | Q Science > QR Microbiology |
| Depositing User: | Dr. Hajar Fauzan Ahmad |
| Date Deposited: | 07 May 2025 06:58 |
| Last Modified: | 07 May 2025 06:58 |
| URI: | http://umpir.ump.edu.my/id/eprint/29964 |
| Download Statistic: | View Download Statistics |
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