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Effect of ultrasonic waves on polymorphism and crystal size distributions of mefenamic acid

Siti Kholijah, Abdul Mudalip and N. A., Sezali and M. R., Abu Bakar (2020) Effect of ultrasonic waves on polymorphism and crystal size distributions of mefenamic acid. In: IOP Conference Series: Materials Science and Engineering; 5th International Conference of Chemical Engineering and Industrial Biotechnology, ICCEIB 2020, 9 - 11 August 2020 , Kuala Lumpur, Malaysia. pp. 1-9., 991 (1). ISSN 1757-8981 (Print); 1757-899X (Online)

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Crystallization of pharmaceutical compound that have different polymorphic forms and broad crystal size distributions remain major challenge in industry. In this present work, the potential of ultrasonic intensifications on crystallization of mefenamic acid polymorph is investigated. The effect of sonication times (5 min – 30 min) and ultrasonic powers (153.3 – 766.7 Watt) at frequency of 65 kHz on polymorphic form and crystals size distributions (CSDs) of mefenamic acid crystals during cooling crystallization were investigated using One-Factor-At-a-Time method (OFAT). The polymorphic form, CSD and shape were determined using Fourier transform infrared spectroscopy (FTIR), Malvern Mastersizer, optical microscope and X-ray diffractometry, respectively. It was found that ultrasonic power of 766.7 Watt and 30 min of sonication time produce plate-shaped crystals with the narrow CSD. The polymorph was consistent with Form I. The findings justify the suitability of ultrasonic waves to produced plate-like mefenamic acid Form I crystals with narrow CSD.

Item Type: Conference or Workshop Item (Lecture)
Additional Information: Indexed by Scopus
Uncontrolled Keywords: Crystallization; Mefenamic acid; Pharmaceutical industries
Subjects: R Medicine > RM Therapeutics. Pharmacology
T Technology > TP Chemical technology
Faculty/Division: Institute of Postgraduate Studies
College of Engineering
Depositing User: Mrs Norsaini Abdul Samat
Date Deposited: 23 Apr 2021 07:17
Last Modified: 23 Apr 2021 07:17
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