Tri-metallic Co-Ni-Cu based metal organic framework nanostructures for the detection of an anticancer drug nilutamide

Akhter, Shamima and Nurul Khairiyyah, Mohd Zain and Md., Shalauddin and Singh, Vivek Kumar and Izan Izwan, Misnon and Sharma, Rajendra Kumar and Das, Santanu and Wan Jeffrey, Basirun and Mohd. Rafie, Johan and Rajan, Jose (2021) Tri-metallic Co-Ni-Cu based metal organic framework nanostructures for the detection of an anticancer drug nilutamide. Sensors and Actuators: A Physical, 325 (112711). pp. 1-11. ISSN 0924-4247. (Published)

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Abstract

This work reports a biosensor based on tri-metallic organic framework (MOF) for the determination of an anticancer therapeutic agent, nilutamide (NLM). The tri-metallic Co-Ni-Cu-MOF and the single metal MOFs Co-MOF, Ni-MOF and Cu-MOF were grown onto nickel foam (NF) substrate by a solvothermal method. The crystal, chemical structure, morphology and surface area of the MOFs were studied by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FESEM), energy dispersive X-ray (EDX) transmission electron microscopy (TEM) and Brunauer-Emmett-Teller (BET) analysis. The electrochemical sensing of NLM by the Co-Ni-Cu-MOF/NF and the single metal MOFs grown onto NF were studied by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). The CV of the Co-Ni-Cu-MOF/NF shows a redox couple between -0.4 V and 0.3 V in phosphate buffer solution at pH 7.0. The Co-Ni-Cu-MOF/NF sensor shows a strong electrocatalytic activity towards the redox reaction of NLM with a broad concentration range from 0.5–70 μM and 70–900 μM with high sensitivity of 10.712 μA μM−1 cm-2 and a low limit of detection of 0.48 ± 0.02 nM. These results confirm that the tri-metallic MOF possesses high selectivity and sensitivity for the determination of NLM from human serum specimen and pharmaceutical tablet dosage forms.

Item Type:	Article
Uncontrolled Keywords:	Tri-metallic Co-Ni-Cu-MOF/NF, Biosensor, Nilutamide, Differential pulse voltammetry, Cyclic voltammetry, Real samples
Subjects:	Q Science > QD Chemistry
Faculty/Division:	Faculty of Industrial Management Institute of Postgraduate Studies
Depositing User:	Noorul Farina Arifin
Date Deposited:	23 Aug 2021 02:33
Last Modified:	23 Aug 2021 02:33
URI:	http://umpir.ump.edu.my/id/eprint/31861
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