A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L.

Hossain, Md. Sanower and Sharfaraz, Ashik and Dutta, Amit and Ahsan, Asif and Masud, Md. Anwarul and Ahmed, Idris Adewale and Goh, Bey Hing and Urbi, Zannat and Sarker, Md. Moklesur Rahman and Ming, Long Chiau (2021) A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L. Biomedicine & Pharmacotherapy, 143 (112182). pp. 1-25. ISSN 0753-3322. (Published)

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Nigella sativa L. is one of the most extensively used traditional medicinal plants. This widely studied plant is known to display diverse pharmacological actions, including antimicrobial activities. Current literature has documented its multi-target mode of antimicrobial actions. N. sativa or its bioactive compounds, such as thymoquinone, can induce oxidative stress, cell apoptosis (by producing reactive oxygen species), increase membrane permeability, inhibit efflux pumps, and impose strong biocidal actions. Despite its well-documented antimicrobial efficacy in the experimental model, to the best of our knowledge its antimicrobial mechanisms highlighting the multi-targeting properties have yet to be well discussed. Is N. sativa or thymoquinone a valuable lead compound for therapeutic development for infectious diseases? Are N. sativa’s bioactive compounds potential antimicrobial agents or able to overcome antimicrobial resistance? This review aims to discuss the antimicrobial pharmacology of N. sativa-based treatments. Additionally, it provides a holistic overview of the ethnobotany, ethnopharmacology, and phytochemistry of N. sativa.

Item Type: Article
Additional Information: Indexed by Scopus
Uncontrolled Keywords: Antibacterial agent; Antibiotic resistance; Bioactive molecules; Medicinal plant; Natural products; Phytochemistry; Toxicology
Subjects: T Technology > TP Chemical technology
Faculty/Division: Faculty of Industrial Sciences And Technology
Institute of Postgraduate Studies
Depositing User: Mrs Norsaini Abdul Samat
Date Deposited: 06 Jan 2022 04:27
Last Modified: 06 Jan 2022 04:27
URI: http://umpir.ump.edu.my/id/eprint/32657
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