Zulkipli, Nur Syahirah and Satari, Siti Zanariah and Hariri, Firdaus and Abdullah, Norli Anida and Wan Yusoff, Wan Nur Syahidah and Hussin, Abdul Ghapor (2022) Cranial morphology associated with syndromic craniosynostosis: A potential detection of abnormality in patient's cranial growth using angular statistics. The Cleft Palate-Craniofacial Journal. pp. 1-10. ISSN 1055-6656. (In Press / Online First) (In Press / Online First)
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Abstract
Introduction: Apert, Crouzon, and Pfeiffer syndromes are common genetic syndromes related to syndromic craniosynostosis (SC), whereby it is a congenital defect that occurs when the cranial growth is distorted. Identifying cranial angles associated with these 3 syndromes may assist the surgical team to focus on a specific cranial part during the intervention planning, thus optimizing surgical outcomes and reducing potential morbidity. Objective: The aim of this study is to identify the cranial angles, which are associated with Apert, Crouzon, and Pfeiffer syndromes. Methods: The cranial computed tomography scan images of 17 patients with SC and 22 control groups aged 0 to 12 years who were treated in the University Malaya Medical Centre were obtained, while 12 angular measurements were attained using the Mimics software. The angular data were then divided into 2 groups (patients aged 0 to 24 months and >24 months). This work proposes a 95% confidence interval (CI) for angular mean to detect the abnormality in patient's cranial growth for the SC syndromes. Results: The 95% CI of angular mean for the control group was calculated and used as an indicator to confirm the abnormality in patient's cranial growth that is associated with the 3 syndromes. The results showed that there are different cranial angles associated with these 3 syndromes. Conclusions: All cranial angles of the patients with these syndromes lie outside the 95% CI of angular mean of control group, indicating the reliability of the proposed CI in the identification of abnormality in the patient's cranial growth.
| Item Type: | Article |
|---|---|
| Additional Information: | Indexed by Scopus |
| Uncontrolled Keywords: | Craniofacial morphology; Apert syndrome; Craniofacial growth; Syndromic craniosynostosis |
| Subjects: | Q Science > QA Mathematics |
| Faculty/Division: | Center for Mathematical Science Institute of Postgraduate Studies |
| Depositing User: | Ms. Siti Zanariah Satari |
| Date Deposited: | 20 Oct 2022 02:12 |
| Last Modified: | 20 Oct 2022 02:12 |
| URI: | http://umpir.ump.edu.my/id/eprint/34457 |
| Download Statistic: | View Download Statistics |
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